Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Abstract

6-Azauracil (6 AU) inhibits enzymes in nucleoside synthesis and depletes the intracellular GTP/UTP pool. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways, exaggerate the growth defect of cells in the presence of 6 AU. Thus, identification of mutations that render cells sensitive to 6 AU will benefit… (More)
DOI: 10.1002/yea.3085

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Cite this paper

@article{Zhou2015GenomewideSO, title={Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.}, author={Huan Zhou and Qi Liu and Tianfang Shi and Yao Yu and Hong Lu}, journal={Yeast}, year={2015}, volume={32 10}, pages={643-55} }