Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes

@article{Straub2002GenomewideSO,
  title={Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes},
  author={Richard E Straub and C J Maclean and Yu Ma and Bradley Todd Webb and Max V Myakishev and Carole Harris-Kerr and Brandon K Wormley and Hannah Sadek and Bharat Kadambi and Francis Anthony O'Neill and Dermot Walsh and Kenneth S. Kendler},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={542-559}
}
From our linkage study of Irish families with a high density of schizophrenia, we have previously reported evidence for susceptibility genes in regions 5q21–31, 6p24–21, 8p22–21, and 10p15–p11. In this report, we describe the cumulative results from independent genome scans of three a priori random subsets of 90 families each, and from multipoint analysis of all 270 families in ten regions. Of these ten regions, three (13q32, 18p11–q11, and 18q22–23) did not generate scores above the empirical… CONTINUE READING

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Fine-mapping of a 40 CM region on chromosome 1Q in schizophrenia [Abstract

  • J Ekelund, I Hovatta, A Parker, T Varilo, T Pauron, R Martin
  • Am J Med Genet
  • 2000

Genome wide linkage analysis supports the presence of two separate susceptibility loci on chromosome 1q32 for biopolar disorder and 1q21–22.3 for schizophrenia [Abstract

  • HMD Gurling, D Curtis, G Kalsi, A McQuillin, J Lawrence, P Murphy
  • Am J Med Genet
  • 2000

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