Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma.

@article{Khoo2009GenomewideSI,
  title={Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma.},
  author={Seok Kooi Khoo and Rokiah Pendek and Radoslav Nickolov and Douglas C Luccio-Camelo and Tiffany Lynn Newton and Aaron Massie and David Petillo and Jegadish Menon and Deborah P Cameron and Bin Tean Teh and S-P Chan},
  journal={Endocrine-related cancer},
  year={2009},
  volume={16 3},
  pages={
          1057-63
        }
}
Isolated familial somatotropinoma (IFS) accounts for 18% of familial isolated pituitary adenoma (FIPA) cases. Recently, germline mutations of the aryl hydrocarbon receptor-interacting protein gene (AIP) have been found in families with pituitary adenoma predisposition, FIPA, and IFS. In this study, we investigate the AIP mutation status and perform a genome-wide scan to search for the modifier regions of acromegalic phenotypes in an IFS family of 31 aborigines from Borneo. Complete endocrine… CONTINUE READING

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