Genome-wide scan demonstrates significant linkage for male sexual orientation

  title={Genome-wide scan demonstrates significant linkage for male sexual orientation},
  author={Alan R. Sanders and Eden R. Martin and Gary W. Beecham and S. Guo and Khytam Dawood and Gerulf Rieger and Judith A. Badner and Elliot S. Gershon and Ritesha S. Krishnappa and Alana B. Kolundzija and Jubao Duan and Pablo V. Gejman and J. Michael Bailey},
  journal={Psychological Medicine},
  pages={1379 - 1388}
Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8… 

Genome-Wide Linkage Study Meta-Analysis of Male Sexual Orientation

The meta-analysis has maximized the positional information from GWLS of currently available family resources and can help prioritize findings from genome-wide association studies (GWAS) and other approaches.

Genome-Wide Linkage and Association Study of Childhood Gender Nonconformity in Males

The strongest linkage peaks, each with significant or suggestive two-point LOD scores and multipoint LOD score support, were on chromosomes 5q31, 6q12, 7q33, and 8q24, with the latter not overlapping with previously reported strongest linkage region for male sexual orientation on pericentromeric chromosome 8.

Genome-Wide Association Study of Male Sexual Orientation

A genome-wide association study of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men using Affymetrix single nucleotide polymorphism (SNP) arrays identified several SNPs with p’< 10−5, including regions of multiple supporting SNPs on chromosomes 13 and 14 that could conceivably help explain past findings relating familial atypical thyroid function and male homosexuality.

Discovery of new genetic loci for male sexual orientation in Han population

A two-stage genome-wide association study with a total sample of 1478 homosexual males and 3313 heterosexual males in Han Chinese populations and identified two genetic loci showing consistent association with male sexual orientation.

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

This genome-wide association study of same-sex sexual behavior identifies loci associated with human sexual orientation that suggest links to biological pathways that involve sex hormone regulation and olfaction and investigates the biology and complexity of the trait.

Alternative Sexual Orientation in Humans: What Is Known and What Needs to Be Known Further

This review tries to explain why natural selection is not eliminating the genetic factors associated with homosexuality even at the cost of the evolutionary fitness of homosexual individuals.

The Discordant Development of Sexual Orientation in Identical Twins

Results suggested that these twins differed in many (but not in all) correlates of their sexual orientation, suggesting non-genetic influences, however, there were also subtle similarities within pairs that pointed to potential familial influences.

Fraternal birth order effect on sexual orientation explained

  • J. Balthazart
  • Psychology
    Proceedings of the National Academy of Sciences
  • 2017
Direct biochemical evidence is presented indicating that the increased incidence of homosexuality in males with older brothers results from a progressive immunization of the mother against a male-specific cell-adhesion protein that plays a key role in cell–cell interactions during development called neuroligin 4 Y-linked, or NLGN4Y.

Analysis of the Association between Catechol-O-Methyltransferase Val158Met and Male Sexual Orientation.

The COMT Val158Met variant might be associated with male sexual orientation and a recessive model was suggested.



A linkage between DNA markers on the X chromosome and male sexual orientation.

Investigation of pedigree and linkage analyses on 114 families of homosexual men found increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population.

A genome-wide scan of male sexual orientation

Single-nucleotide polymorphism (SNP)based scans for linkage provide significantly greater genomic coverage and information content than do microsatellite assays; hence, this technology was applied to study a Canadian cohort of homosexual males.

A genomewide scan of male sexual orientation

The results of this first genome screen for normal variation in the behavioral trait of sexual orientation in males should encourage efforts to replicate these findings in new samples with denser linkage maps in the suggested regions.

Genetics and Male Sexual Orientation

It appears to us that the family pedigree data from the Canadian study actually support the Xq28 hypothesis; three other availableXq28 DNA studies did find linkage; and the heritability of sexual orientation is supported by substantial evidence independent of the X-chromosome linkage data.

Linkage between sexual orientation and chromosome Xq28 in males but not in females

DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.

Genetic and Environmental Effects on Same-sex Sexual Behavior: A Population Study of Twins in Sweden

Data from a truly population-based 2005–2006 survey of all adult twins in Sweden is used to conduct the largest twin study of same-sex sexual behavior attempted so far, and results are consistent with moderate, primarily genetic, familial effects, and moderate to large effects of the nonshared environment (social and biological) on same- sex sexual behavior.

Male homosexuality: absence of linkage to microsatellite markers at Xq28.

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on

A Family History Study of Male Sexual Orientation Using Three Independent Samples

The results differed significantly with those of some prior studies, but they do not exclude the possibility of moderate X-linkage for male sexual orientation, and the importance of familial factors for male homosexuality.

Genetic and Environmental Influences on Female Sexual Orientation, Childhood Gender Typicality and Adult Gender Identity

A large sample of British female twins completed a questionnaire assessing sexual attraction, CGT and AGI indicated that a single latent variable influenced by a genetic component and common non-shared environmental component explained the association between the three traits but there was substantial measurement error.

A Critical Review of Recent Biological Research on Human Sexual Orientation

A comprehensive review and critique of biological research on sexual orientation published over the last decade is provided, including measurement issues, cognitive, and psychophysiological issues, and lack of research on women.