Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis.

@article{Sala2009GenomewideRA,
  title={Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis.},
  author={Claudia Sala and Ahmed Haouz and Frederick A. Saul and Isabelle Miras and Ida Rosenkrands and Pedro M Alzari and Stewart T Cole},
  journal={Molecular microbiology},
  year={2009},
  volume={71 5},
  pages={1102-16}
}
Comparative genomics with Staphylococcus aureus suggested the existence of a regulatory system governing beta-lactamase (BlaC) production in Mycobacterium tuberculosis. The crystal structure of Rv1846c, a winged helix regulator of previously unknown function, was solved thus revealing strong similarity to the BlaI and MecI repressors of S. aureus, which both respond to beta-lactam treatment. Using chromatin immunoprecipitation and hybridization to microarrays (ChIP-on-chip), the Rv1846c regulon… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…