Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury

@inproceedings{Manners2016GenomewideRO,
  title={Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury},
  author={M T Manners and Adam Ertel and Yuzhen Tian and Seena K. Ajit},
  booktitle={Epigenetics & Chromatin},
  year={2016}
}
Methyl-CpG-binding protein 2 (MeCP2), a protein with affinity for methylated cytosines, is crucial for neuronal development and function. MeCP2 regulates gene expression through activation, repression and chromatin remodeling. Mutations in MeCP2 cause Rett syndrome, and these patients display impaired nociception. We observed an increase in MeCP2 expression in mouse dorsal root ganglia (DRG) after peripheral nerve injury. The functional implication of increased MeCP2 is largely unknown. To… CONTINUE READING
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