Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism.

@article{Hatanaka2010GenomewidePO,
  title={Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism.},
  author={Fumiyuki Hatanaka and Chiaki Matsubara and Jihwan Myung and Takashi Yoritaka and Naoko Kamimura and Shuichi Tsutsumi and Akinori Kanai and Yutaka Suzuki and Paolo Sassone-Corsi and Hiroyuki Aburatani and Sumio Sugano and Toru Takumi},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 24},
  pages={5636-48}
}
Circadian rhythms are common to most organisms and govern much of homeostasis and physiology. Since a significant fraction of the mammalian genome is controlled by the clock machinery, understanding the genome-wide signaling and epigenetic basis of circadian gene expression is essential. BMAL1 is a critical circadian transcription factor that regulates genes via E-box elements in their promoters. We used multiple high-throughput approaches, including chromatin immunoprecipitation-based… CONTINUE READING

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