Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

@inproceedings{Lveill2015GenomewidePO,
  title={Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA},
  author={Nicolas L{\'e}veill{\'e} and Carlos Andr{\'e} Ara{\'u}jo Melo and Koos Rooijers and Angel D{\'i}az-Lagares and S{\'o}nia A. Melo and Gozde Korkmaz and Rui P. Lopes and Farhad Akbari Moqadam and Ana Rita Ramada Maia and Patrick J E C Wijchers and Geert Geeven and Monique L den Boer and Raghu Kalluri and Wouter de Laat and Manel Esteller and Reuven Agami},
  booktitle={Nature communications},
  year={2015}
}
p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-binding sites, most did not. As long non-coding RNAs (lncRNAs) are prominent regulators of chromatin dynamics, we hypothesized that p53-induced lncRNAs contribute to the activation of enhancers by p53. Among p53-induced lncRNAs, we identified LED and demonstrate that its suppression… CONTINUE READING