Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma.

  title={Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma.},
  author={Noriyuki Omura and Chung-Pin Li and Ang Li and Seung-Mo Hong and Kimberly Walter and Antonio J. Jimeno and Maartje Hidalgo and Michael Goggins},
  journal={Cancer biology & therapy},
  volume={7 7},
UNLABELLED Many genes undergo aberrant methylation in human cancers, and microarray platforms enable more comprehensive profiling of aberrant DNA methylation patterns. RESULTS 1,010 of 87,922 probes on the 88 K promoter array (606 genes) had a higher signal (log(2) > 2) in the pancreatic cancer line, Panc-1 compared to the non-neoplastic pancreatic duct line, HPDE. Using this cut-off, bisulfite sequencing and/or MSP confirmed differential methylation of all 27 genes (66 probes) predicted to… CONTINUE READING


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