Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

  title={Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.},
  author={Laura L. Elo and Henna J{\"a}rvenp{\"a}{\"a} and Soile Tuomela and Sunil Raghav and Helena Ahlfors and Kirsti Laurila and Bhawna Gupta and R J Lund and Johanna Tahvanainen and R. David Hawkins and Matej Ore{\vs}i{\vc} and Harri L{\"a}hdesm{\"a}ki and Omid Rasool and Kanury V. S. Rao and Tero Aittokallio and Riitta Lahesmaa},
  volume={32 6},
Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and… CONTINUE READING


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