Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease

@article{Tan2010GenomeWP,
  title={Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease},
  author={Michelle Guet Khim Tan and Wei T Chua and Margaret M. Esiri and A David Smith and Harry V. Vinters and Mitchell Kim Peng Lai},
  journal={Journal of Neuroscience Research},
  year={2010},
  volume={88}
}
  • M. Tan, W. Chua, +3 authors M. Lai
  • Published 23 November 2009
  • Biology
  • Journal of Neuroscience Research
Alzheimer's disease (AD) is characterized by a complex neurodegenerative process affecting multiple genes and proteins in the neocortex, many of which have not been well‐studied. In this study, we investigated genome‐wide gene alterations in the temporal cortex of a well‐characterized cohort of AD patients using a recently developed microarray platform, and compared some of the transcript changes with immunoblotting. Of the 5485 genes found to be significantly altered in AD, there were… 
View on Wiley
nuhs.edu.sg
94 Citations
Highly Influential Citations
9
Background Citations
34
Methods Citations
2
Results Citations
8

94 Citations

Citation Type

Citation Type

Gene expression profiling in Alzheimer's disease brain microvessels.
TLDR
More than 2,000 genes are differentially altered in AD microvessels and a large number of these genes map to pathways associated with immune and inflammatory response, signal transduction, and nervous system development and function categories, which may help elucidate heretofore unknown molecular alterations in the AD cerebromicrovasculature.
Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study
TLDR
Genes involved in noninsulin-dependent DM and obesity were significantly altered in both AD brains and the AD mouse model, as were genes related to psychiatric disorders and AD.
Gene expression profiling in human neurodegenerative disease
TLDR
This Review summarizes microarray human GEP studies in the common neurodegenerative diseases amyotrophic lateral sclerosis (ALS), Parkinson disease (PD) and Alzheimer disease (AD) and provides a discussion of methodological considerations in microarray sample preparation and data analysis.
Cortical Transcriptional Profiles in APOE4 Carriers with Alzheimer's Disease: Patterns of Protection and Degeneration.
TLDR
The results indicate that many of the molecular changes identified in the brains of patients with AD reflect the non-specific consequences of neurodegeneration, rather than causative processes.
Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain
TLDR
The hypothesis that at least part of the synaptic failure characterizing AD may result from aberrant CN activation leading to down‐regulation of synaptic genes, potentially via activation of specific transcription factors and expression of repressive microRNAs is supported.
Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease
TLDR
A pathway analysis of a whole genome AD case-control expression dataset from the human temporal cortex tissue identified significant KEGG pathways related to metabolism and immune processes and found most of these pathways are shared in both GWAS and expression datasets.
Identification of dysregulated genes and pathways of different brain regions in Alzheimer’s disease
TLDR
The DEGs including YAP1, MAPK1, GJA1 and pathways including MAPK signaling pathway and Wnt signaling pathway may be related to AD progression and RAD51C, SAFB2, SSH3 and TXNDC9 might be potential biomarkers in AD diagnosis.
Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions
TLDR
An integrated analysis of five different brain region datasets is presented and new genes related with AD are introduced and introduced that may provide new insights into the disease mechanisms and thus make a significant contribution in the near future towards understanding, prevention and cure of AD.
A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation
TLDR
The results suggest that the down-regulation of a metastable subproteome may help mitigate aberrant protein aggregation when protein homeostasis becomes compromised in Alzheimer’s disease.
Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer’s disease
TLDR
Genes regulated by Trichostatin A treatment were found to significantly overlap with differentially expressed genes in the Alzheimer’s disease (AD) brain and it was shown that the expression of hemoglobin, which has been shown to be altered in neurons in the AD brain, is regulated by TSA treatment.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
A gene expression profile of Alzheimer's disease.
TLDR
A gene expression profile for AD brain showed that 118 of the 7050 sequences on a broadly representative cDNA microarray were differentially expressed in the amygdala and cingulate cortex, two regions affected early in the disease.
A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging
TLDR
The transcriptional network in AD was characterized, identifying 12 distinct modules related to synaptic and metabolic processes, immune response, and white matter, nine of which were related to disease progression, and presenilin 1 (PSEN1) is highly coexpressed with canonical myelin proteins, suggesting a role for PSEN1 in aspects of glial-neuronal interactions related to neurodegenerative processes.
Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease
Expression profile of transcripts in Alzheimer's disease tangle‐bearing CA1 neurons
TLDR
The profile of mRNAs differentially expressed by tangle‐bearing CA1 neurons may represent a “molecular fingerprint” of these neurons, and it is speculated that mRNA expression profiles of diseased neurons in AD may suggest new directions for AD research or identify novel targets for developing more effective AD therapies.
Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling
Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
TLDR
A new model of AD pathogenesis is suggested in which a genomically orchestrated up-regulation of tumor suppressor-mediated differentiation and involution processes induces the spread of pathology along myelinated axons.
Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
TLDR
Evidence supports the feasibility and usefulness of cDNA microarray techniques to study sequential changes of distinctive gene‐expression patterns in the brain as a function of the progression of AD dementia and suggests new means to dissect and classify stages ofAD dementia, or neuropathology, at the molecular level.
Transcriptome Analysis of Synaptoneurosomes Identifies Neuroplasticity Genes Overexpressed in Incipient Alzheimer's Disease
TLDR
A novel approach concentrates synaptic mRNA, thereby increasing the ratio of synaptic to somal mRNA and allowing discrimination of expression changes in synaptically localized genes, and implies a functional impact on synaptic transmission as GluR2, if inserted, maintains the receptors in a low conductance state.
Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray.
TLDR
This study suggests that CAbeta may play a crucial role in the pathophysiological mechanisms in AD.
Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: Statistical reliability and functional correlation
...
1
2
3
4
5
...