Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.

@article{Nielsen2008GenomewidePO,
  title={Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.},
  author={Ronni Nielsen and Thomas Askov Pedersen and Dik Hagenbeek and Panagiotis Moulos and Rasmus Siersbaek and Eva Megens and Sergei Denissov and Michael B\orgesen and Kees-Jan Françoijs and S Mandrup and Hendrik G. Stunnenberg},
  journal={Genes & development},
  year={2008},
  volume={22 21},
  pages={2953-67}
}
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key regulator of adipocyte differentiation in vivo and ex vivo and has been shown to control the expression of several adipocyte-specific genes. In this study, we used chromatin immunoprecipitation combined with deep sequencing to generate genome-wide maps of PPARgamma and retinoid X receptor (RXR)-binding sites, and RNA polymerase II (RNAPII) occupancy at very high resolution throughout adipocyte… CONTINUE READING
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