Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum

@inproceedings{Cadet2013GenomewidePI,
  title={Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum},
  author={Jean Lud Cadet and Subramaniam Jayanthi and Michael T. Mccoy and Bruce Ladenheim and Fabienne Saint-Preux and Elin Lehrmann and Supriyo De and Kevin G. Becker and Christie Brannock},
  booktitle={BMC Genomics},
  year={2013}
}
METH is an illicit drug of abuse that influences gene expression in the rat striatum. Histone modifications regulate gene transcription. We therefore used microarray analysis and genome-scale approaches to examine potential relationships between the effects of METH on gene expression and on DNA binding of histone H4 acetylated at lysine 4 (H4K5Ac) in the rat dorsal striatum of METH-naïve and METH-pretreated rats. Acute and chronic METH administration caused differential changes in striatal gene… CONTINUE READING
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