Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort.

@article{Spycher2012GenomewidePO,
  title={Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort.},
  author={Ben D Spycher and John Brooks Henderson and Raquel Granell and David M. Evans and George Davey Smith and Nicholas John Timpson and Jonathan A C Sterne},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={130 2},
  pages={
          503-9.e7
        }
}
BACKGROUND Childhood wheezing and asthma vary greatly in clinical presentation and time course. The extent to which phenotypic variation reflects heterogeneity in disease pathways is unclear. OBJECTIVE We sought to assess the extent to which single nucleotide polymorphisms (SNPs) associated with childhood asthma in a genome-wide association study are predictive of asthma-related phenotypes. METHODS In 8365 children from a population-based birth cohort, the Avon Longitudinal Study of Parents… CONTINUE READING

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