Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions.

@article{Zhu2006GenomewideOP,
  title={Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions.},
  author={Xuefeng Zhu and Marianna Wir{\'e}n and Indranil Sinha and Nina N. Rasmussen and Tomas Linder and Steen Holmberg and Karl Ekwall and Claes M Gustafsson},
  journal={Molecular cell},
  year={2006},
  volume={22 2},
  pages={
          169-78
        }
}
Mediator exists in a free form containing the Med12, Med13, CDK8, and CycC subunits (the Srb8-11 module) and a smaller form, which lacks these four subunits and associates with RNA polymerase II (Pol II), forming a holoenzyme. We use chromatin immunoprecipitation (ChIP) and DNA microarrays to investigate genome-wide localization of Mediator and the Srb8-11 module in fission yeast. Mediator and the Srb8-11 module display similar binding patterns, and interactions with promoters and upstream… CONTINUE READING
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