Genome-wide nucleosome positioning during embryonic stem cell development

  title={Genome-wide nucleosome positioning during embryonic stem cell development},
  author={V. B. Teif and Y. Vainshtein and Ma{\"i}wen Caudron-Herger and Jan-Philipp Mallm and C. Marth and T. H{\"o}fer and K. Rippe},
  journal={Nature Structural &Molecular Biology},
  • V. B. Teif, Y. Vainshtein, +4 authors K. Rippe
  • Published 2012
  • Medicine, Biology
  • Nature Structural &Molecular Biology
  • We determined genome-wide nucleosome occupancies in mouse embryonic stem cells and their neural progenitor and embryonic fibroblast counterparts to assess features associated with nucleosome positioning during lineage commitment. Cell-type- and protein-specific binding preferences of transcription factors to sites with either low (Myc, Klf4 and Zfx) or high (Nanog, Oct4 and Sox2) nucleosome occupancy as well as complex patterns for CTCF were identified. Nucleosome-depleted regions around… CONTINUE READING
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