Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome.

  title={Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome.},
  author={Jakob Skou Pedersen and Eivind Valen and Amhed Missael Vargas Velazquez and Brian J. Parker and Morten Rasmussen and Stinus Lindgreen and Berit Lilje and Desmond J. Tobin and Theresa K. Kelly and S{\o}ren Vang and Robin Andersson and Peter A. Jones and Cindi A. Hoover and Alexei N. Tikhonov and Egor Prokhortchouk and Edward M. Rubin and Albin Sandelin and M. Thomas P. Gilbert and Anders Krogh and Eske Willerslev and Ludovic Orlando},
  journal={Genome research},
  volume={24 3},
Epigenetic information is available from contemporary organisms, but is difficult to track back in evolutionary time. Here, we show that genome-wide epigenetic information can be gathered directly from next-generation sequence reads of DNA isolated from ancient remains. Using the genome sequence data generated from hair shafts of a 4000-yr-old Paleo-Eskimo belonging to the Saqqaq culture, we generate the first ancient nucleosome map coupled with a genome-wide survey of cytosine methylation… 

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