Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau

@article{Devlin2002GenomewideML,
  title={Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau},
  author={Bernie J Devlin and S A Bacanu and Kathyrn Roeder and Fred W. Reimherr and Paul Wender and Brandi L Galke and D Novasad and Ashley L Chu and K TCuenco and S Tiobek and Caleb Otto and William Byerley},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={689-694}
}
The oceanic nation of Palau has been geographically and culturally isolated over most of its 2000 year history. As part of a study of the genetic basis of schizophrenia in Palau, we genotyped five large, multigenerational schizophrenia pedigrees using markers every 10 cM (CHLC/Weber screening set 6). The number of affected/unaffected individuals genotyped per family ranged from 11/21 to 5/5. Thus the pedigrees varied in their information for linkage, but each was capable of producing a… CONTINUE READING

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