Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays

  title={Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays},
  author={Antti Honkela and Jaakko Peltonen and Hande Topa and Iryna Charapitsa and Filomena Matarese and Korbinian Grote and Hendrik G. Stunnenberg and George Reid and Neil D. Lawrence and Magnus Rattray},
  journal={Proceedings of the National Academy of Sciences},
  pages={13115 - 13120}
Significance Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing… 

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