Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers.

@article{Heller2012GenomewideME,
  title={Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers.},
  author={Gerwin Heller and Marlene Weinzierl and Christian Noll and Valerie N Babinsky and Barbara R Ziegler and Corinna Altenberger and Christoph Minichsdorfer and Gyoergy Lang and Bal{\'a}zs D{\"o}me and Adelheid End-Pf{\"u}tzenreuter and Britt-Madeleine Arns and Yuliya Grin and Walter Klepetko and Christoph Carl Zielinski and Sabine Zoechbauer-Mueller},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 6},
  pages={1619-29}
}
PURPOSE The major aim of this study was to investigate the role of DNA methylation (referred to as methylation) on miRNA silencing in non-small cell lung cancers (NSCLC). EXPERIMENTAL DESIGN We conducted microarray expression analyses of 856 miRNAs in NSCLC A549 cells before and after treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (Aza-dC) and with a combination of Aza-dC and the histone deacetylase inhibitor trichostatin A. miRNA methylation was determined in 11… CONTINUE READING
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