Genome-wide methylation analysis of prostate tissues reveals global methylation patterns of prostate cancer.

@article{Luo2013GenomewideMA,
  title={Genome-wide methylation analysis of prostate tissues reveals global methylation patterns of prostate cancer.},
  author={J H Luo and Ying Ding and Rui Chen and George K Michalopoulos and Joel B. Nelson and George C. Tseng and Yan Ping Yu},
  journal={The American journal of pathology},
  year={2013},
  volume={182 6},
  pages={2028-36}
}
Altered genome methylation is a hallmark of human malignancies. In this study, high-throughput analyses of concordant gene methylation and expression events were performed for 91 human prostate specimens, including prostate tumor (T), matched normal adjacent to tumor (AT), and organ donor (OD). Methylated DNA in genomic DNA was immunoprecipitated with anti-methylcytidine antibodies and detected by Affymetrix human whole genome SNP 6.0 chips. Among the methylated CpG islands, 11,481 islands were… CONTINUE READING
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Gene deletions and ajp.amjpathol.org - The American Journal of Pathology

  • MA Nalesnik, G Tseng, +6 authors JH Luo
  • Am J Pathol 2012,
  • 2013
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