Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.

@article{Revill2013GenomewideMA,
  title={Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.},
  author={K. L. Revill and Tim Sen Wang and Anja Lachenmayer and Kensuke Kojima and Andrew W. Harrington and Jinyu Li and Yujin Hoshida and Josep M Llovet and Scott Powers},
  journal={Gastroenterology},
  year={2013},
  volume={145 6},
  pages={1424-35.e1-25}
}
BACKGROUND & AIMS Epigenetic silencing of tumor suppressor genes contributes to the pathogenesis of hepatocellular carcinoma (HCC). To identify clinically relevant tumor suppressor genes silenced by DNA methylation in HCC, we integrated DNA methylation data from human primary HCC samples with data on up-regulation of gene expression after epigenetic unmasking. METHODS We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina HumanBeadchip27K array; data were… CONTINUE READING
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