Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

@article{Suri2018GenomewideMO,
  title={Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain},
  author={Pradeep Suri and Melody R Palmer and Yakov A. Tsepilov and Maxim B. Freidin and Cindy Germaine Boer and Michelle S Yau and Daniel S. Evans and Andrea Gelemanovi{\'c} and Traci M Bartz and Maria Nethander and Liubov Arbeeva and Lennart C. Karssen and Tuhina Neogi and Archie I Campbell and Dan Mellstrom and Claes Ohlsson and Lynn M Marshall and Eric S. Orwoll and Andr{\'e} G. Uitterlinden and Jerome I. Rotter and Gordan Lauc and Bruce M. Psaty and Magnus K. Karlsson and Nancy E. Lane and Gail P. Jarvik and Ozren Pola{\vs}ek and Marc C. Hochberg and Joanne M. Jordan and Joyce B.J. van Meurs and Rebecca D. Jackson and Carrie M Nielson and Braxton D. Mitchell and Blair H. Smith and Caroline Hayward and Nicholas L. Smith and Yurii S. Aulchenko and Frances M. K. Williams},
  journal={PLoS Genetics},
  year={2018},
  volume={14}
}
Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from the UK Biobank interim data release. CBP cases were defined as those reporting back pain present for… Expand
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