Genome-wide meta-analysis identifies new susceptibility loci for migraine

  title={Genome-wide meta-analysis identifies new susceptibility loci for migraine},
  author={Verneri Anttila and Bendik S Winsvold and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George Mcmahon and Mikko Kallela and Rainer Malik and Boukje de Vries and Gisela M. Terwindt and Sarah E. Medland and Unda Todt and Wendy L. Mcardle and L. A. N. Quaye and Markku Koiranen and M. Arfan Ikram and Terho Lehtim{\"a}ki and Anine H. Stam and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Benjamin M. Neale and Priit Palta and Eija I Hamalainen and Markus Schuerks and Lynda M. Rose and Julie E. Buring and Paul M. Ridker and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Debbie A Lawlor and David M. Evans and Susan M. Ring and Markus F{\"a}rkkil{\"a} and Ville Artto and Mari Anneli Kaunisto and Tobias M. Freilinger and Jean E Schoenen and Rune R. Frants and Nadine Pelzer and C. M. Kellett S. R. Weller and Ronald Zielman and A Christopher Heath and Pamela A. F. Madden and Grant W. Montgomery and Nicholas G. Martin and Guntram Borck and Hartmut Goebel and Axel Heinze and Katja Heinze-Kuhn and Frances M. K. Williams and A Hartikainen and Anneli Pouta and Joyce van den Ende and Andr{\'e} G. Uitterlinden and Albert Hofman and Najaf Amin and Jouke-Jan Hottenga and Jacqueline M. Vink and Kauko Heikkil{\"a} and Michael Alexander and Bertram Muller-Myhsok and Stefan Schreiber and Thomas Meitinger and H. E. Wichmann and Arpo R J Aromaa and Johan G Eriksson and Bryan J. Traynor and Daniah Trabzuni and Elizabeth J. Rossin and Kasper Lage and Suzanne B R Jacobs and Jesse Raphael Gibbs and Ewan Birney and Jaakko Kaprio and Brenda W J H Penninx and Dorret I. Boomsma and Cornelia M van Duijn and Olli T. Raitakari and Marjo-Riitta Jarvelin and John Anker H Zwart and Lynn F. Cherkas and David P. Strachan and Christian Kubisch and Michel D. Ferrari and Arn M J M van den Maagdenberg and Martin Dichgans and Maija Wessman and George Davey Smith and K{\'a}ri Stef{\'a}nsson and Mark J. Daly and Dale R. Nyholt and Daniel Chasman and Aarno V Palotie},
  booktitle={Nature Genetics},
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10−8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16… CONTINUE READING
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