Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

  title={Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture},
  author={Sonja I. Berndt and Stefan Gustafsson and Reedik M{\"a}gi and Andrea Ganna and Eleanor Wheeler and Mary F Feitosa and Anne E Justice and Keri L. Monda and Damien C. Croteau-Chonka and Felix R Day and T{\"o}nu Esko and Tove Fall and Teresa M. Ferreira and Davide Gentilini and Anne U. Jackson and Jian’an Luan and Joshua C. Randall and Sailaja L Vedantam and Cristen J. Willer and Thomas W. Winkler and Andrew R Wood and Tsegaselassie Workalemahu and Yi-Juan Hu and Sang Hong Lee and Liming Liang and Dan-Yu Lin and Josine L. Min and Benjamin M. Neale and Gudmar Thorleifsson and Jian Yang and Eva Albrecht and Najaf Amin and Jennifer Bragg-Gresham and Gemma Cadby and Martin den Heijer and Niina Eklund and Krista Fischer and Anuj Goel and Jouke-Jan Hottenga and Jennifer E Huffman and Ivonne Jarick and {\AA}sa Johansson and Toby Johnson and Stavroula Kanoni and Marcus E. Kleber and Inke R. K{\"o}nig and Kati Kristiansson and Zolt{\'a}n Kutalik and Claudia Lamina and Cecile Lecoeur and Guo Tao Li and Massimo Mangino and Wendy L. Mcardle and Carolina Medina-Gomez and Martina M{\"u}ller-Nurasyid and Julius Suh Ngwa and Ilja M. Nolte and Lavinia Paternoster and Sonali Pechlivanis and Markus Perola and Marjolein J. Peters and Michael Preuss and Lynda M. Rose and Jianxin Shi and Dmitry Shungin and Albert Vernon Smith and Rona J. Strawbridge and Ida L Surakka and Alexander Teumer and Mieke D. Trip and Jonathan P. Tyrer and Jana V van Vliet-Ostaptchouk and Liesbeth Vandenput and Lindsay L. Waite and Jing Hua Zhao and Devin M Absher and Folkert W. Asselbergs and Mustafa Atalay and Antony Paul Attwood and Anthony J. Balmforth and Hanneke V Basart and John Beilby and Lori L. Bonnycastle and Paolo Brambilla and Marcel Bruinenberg and Harry Campbell and Daniel Chasman and Peter S. Chines and Francis S. Collins and John M. Connell and William O C M Cookson and Ulf H de Faire and Femmie de Vegt and Mariano Dei and Maria Dimitriou and Sarah J Edkins and Karol Estrada and David M. Evans and Martin Farrall and Marco Mario Ferrario and Jean Ferri{\`e}res and Lude Franke and Francesca Frau and Pablo V. Gejman and Harald Grallert and Henrik Gr{\"o}nberg and Vilmundur Gudnason and Alistair Scott Hall and Per F L Hall and A Hartikainen and Caroline Hayward and Nancy L Heard-Costa and A Christopher Heath and Johannes Hebebrand and Georg Homuth and Frank B Hu and Sarah E. Hunt and Elina Hypp{\"o}nen and Carlos Iribarren and Kevin B. Jacobs and J. -O. Jansson and Antti M. Jula and Mika A. P. K{\"a}h{\"o}nen and Sekar Kathiresan and Frank Kee and Kay-Tee Khaw and Mika Kivimaki and Wolfgang K{\"o}nig and Aldi Kraja and Meena Kumari and Kari A Kuulasmaa and Johanna Kuusisto and Jaana H. Laitinen and Timo A Lakka and Claudia Langenberg and Lenore J. Launer and Lars Lind and Jaana Lindstr{\"o}m and Jianjun Liu and Antonio Liuzzi and Marja-Liisa L Lokki and Mattias Lorentzon and Pamela A. F. Madden and Patrik K E Magnusson and Paolo Manunta and Diana Marek and Winfried Maerz and Irene Mateo Leach and Barbara Mcknight and Sarah E. Medland and Evelin Mihailov and Lili Milani and Grant W. Montgomery and Vincent Mooser and Thomas W. M{\"u}hleisen and Patricia B. Munroe and Arthur William Musk and Narisu Narisu and Gerjan J. Navis and George Nicholson and Ellen A Nohr and Ken K Ong and Ben A. Oostra and Colin N A Palmer and Aarno V Palotie and John F. Peden and Nancy L Pedersen and Annette Peters and Ozren Pola{\vs}ek and Anneli Pouta and Peter P. Pramstaller and Inga Prokopenko and Carolin Puetter and Aparna Radhakrishnan and Olli T. Raitakari and Augusto Rendon and Fernando Rivadeneira and Igor Rudan and Timo E. Saaristo and Jennifer G. Sambrook and Alan R. Sanders and Serena Sanna and Jouko Saramies and Sabine Schipf and Stefan Schreiber and Heribert Schunkert and So-Youn Shin and Stefano G. Signorini and Juha Sinisalo and Boris Skrobek and Nicole Soranzo and Alena Stan{\vc}{\'a}kov{\'a} and Klaus J Stark and Jonathan C. Stephens and Kathleen E. Stirrups and Ronald P. Stolk and Michael Stumvoll and Amy J. Swift and Eirini V. Theodoraki and Barbara Thorand and D A Tregouet and Elena Tremoli and Melanie M. van der Klauw and Joyce B. J. van Meurs and Sita H. H. M. Vermeulen and Jorma S. A. Viikari and Jarmo R Virtamo and Veronique Vitart and G{\'e}rard Waeber and Zhaoming Wang and Elisabeth I M Widen and Sarah H Wild and Gonneke A H M Willemsen and Bernhard Rudolf Winkelmann and Jacqueline C. M. Witteman and Bruce H. R. Wolffenbuttel and Andrew T. Wong and Alan F. Wright and M C Carola Zillikens and Philippe Amouyel and B O Boehm and Eric Boerwinkle and Dorret I. Boomsma and Mark J. Caulfield and Stephen J. Chanock and L. Adrienne Cupples and Daniele Cusi and George V. Z. Dedoussis and Jeanette Erdmann and Johan G Eriksson and Paul W Franks and Philippe Froguel and Christian Gieger and Ulf Gyllensten and Anders Hamsten and Tamara B. Harris and Christian Hengstenberg and Andrew A Hicks and Aroon D. Hingorani and Anke Hinney and Albert Hofman and Kees G. Hovingh and Kristian Hveem and Thomas Illig and Marjo-Riitta Jarvelin and Karl-Heinz J{\"o}ckel and Sirkka M. Keinanen-Kiukaanniemi and Lambertus A Kiemeney and Diana Kuh and Markku Laakso and Terho Lehtim{\"a}ki and Douglas F. Levinson and Nicholas G. Martin and Andres Metspalu and Andrew D. Morris and Markku S Nieminen and Inger Nj\olstad and C Ohlsson and Albertine J Oldehinkel and Willem H Ouwehand and Lyle John Palmer and Brenda W J H Penninx and Chris Power and Michael A. Province and Bruce M. Psaty and Lu Qi and Rainer Rauramaa and Paul M. Ridker and Samuli Ripatti and Veikko V Salomaa and Nilesh J. Samani and Harold Snieder and Thorkild I. A. S\orensen and Tim D. Spector and K{\'a}ri Stef{\'a}nsson and Anke Toenjes and Jaakko Tuomilehto and Andr{\'e} G. Uitterlinden and Matti Uusitupa and Pim van der Harst and Peter Vollenweider and Henri Wallaschofski and Nicholas J Wareham and Hugh C Watkins and H Erich Wichmann and James F Wilson and Gonçalo R. Abecasis and Themistocles L. Assimes and In{\^e}s Barroso and Michael Boehnke and Ingrid B. Borecki and Panagiotis Deloukas and Caroline Fox and Timothy M. Frayling and Leif Groop and Talin Haritunian and Iris M. Heid and David J. Hunter and Robert C. Kaplan and Fredrik Karpe and Miriam F Moffatt and Karen L. Mohlke and Jeffrey R. O’Connell and Yudi Pawitan and Eric E. Schadt and David Schlessinger and Valgerdur Steinthorsdottir and David P. Strachan and Unnur Thorsteinsdottir and Cornelia M van Duijn and Peter M. Visscher and Anna M. Di Blasio and Joel Hirschhorn and Cecilia M. Lindgren and Andrew P. Morris and David Meyre and Andr{\'e} Scherag and Mark I. McCarthy and Elizabeth K. Speliotes and Kari E. North and Ruth J. F. Loos and Erik Ingelsson},
  booktitle={Nature Genetics},
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A… CONTINUE READING

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