Genome-wide mechanisms of Smad binding

  title={Genome-wide mechanisms of Smad binding},
  author={Mako Morikawa and Daizo Koinuma and Kosuke Miyazono and C-H Heldin},
A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We describe current knowledge of cell-type-specific binding patterns of Smad proteins and mechanisms of transcriptional regulation, obtained from recent studies on genome-wide binding… CONTINUE READING
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