Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints

@article{Michels2006GenomeWM,
  title={Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints},
  author={E. Michels and J. Vandesompele and J. Hoebeeck and B. Menten and K. de Preter and G. Laureys and N. Van Roy and F. Speleman},
  journal={Cytogenetic and Genome Research},
  year={2006},
  volume={115},
  pages={273 - 282}
}
  • E. Michels, J. Vandesompele, +5 authors F. Speleman
  • Published 2006
  • Biology, Medicine
  • Cytogenetic and Genome Research
  • In the past few years high throughput methods for assessment of DNA copy number alterations have witnessed rapid progress. Both ‘in house’ developed BAC, cDNA, oligonucleotide and commercial arrays are now available and widely applied in the study of the human genome, particularly in the context of disease. Cancer cells are known to exhibit DNA losses, gains and amplifications affecting tumor suppressor genes and proto-oncogenes. Moreover, these patterns of genomic imbalances may be associated… CONTINUE READING
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