Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution

@article{Sahln2015GenomewideMO,
  title={Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution},
  author={Pelin Sahl{\'e}n and Ilgar Abdullayev and Daniel Ramsk{\"o}ld and Liudmila Matskova and Nemanja Rilakovic and Britta L{\"o}tstedt and Thomas J. Albert and Joakim Lundeberg and Rickard Sandberg},
  journal={Genome Biology},
  year={2015},
  volume={16},
  pages={1-13}
}
Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed HiCap, which combines a 4-cutter restriction enzyme Hi-C with sequence capture of promoter regions. Applying the method to mouse embryonic stem cells, we identified promoter-anchored interactions involving 15,905 promoters and 71,984 distal regions. The distal regions were enriched for enhancer marks and transcription, and had a mean… CONTINUE READING
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