Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes

@inproceedings{Aymard2017GenomeWM,
  title={Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes},
  author={François Aymard and Marion Aguirrebengoa and Emmanuelle Guillou and Biola Maria Javierre and B{\'e}atrix Bugler and Coline Arnould and Vincent Rocher and Jason S. Iacovoni and Anna Biernacka and Magdalena Skrzypczak and Krzysztof Ginalski and Maga Rowicka and Peter Fraser and Ga{\"e}lle Legube},
  booktitle={Nature Structural &Molecular Biology},
  year={2017}
}
The ability of DNA double-strand breaks (DSBs) to cluster in mammalian cells has been a subject of intense debate in recent years. Here we used a high-throughput chromosome conformation capture assay (capture Hi-C) to investigate clustering of DSBs induced at defined loci in the human genome. The results unambiguously demonstrated that DSBs cluster, but only when they are induced within transcriptionally active genes. Clustering of damaged genes occurs primarily during the G1 cell-cycle phase… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 62 references

A mechanism for the suppression of homologous recombination in G1 cells

  • A Orthwein
  • 2016

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

  • K Tsouroula
  • Molecular cell
  • 2016

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