Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1.

@article{Zhao2010GenomewideMO,
  title={Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1.},
  author={Chunyan Zhao and Hui Gao and Yawen Liu and Zoi Melina Papoutsi and Sadaf Jaffrey and Jan-{\AA}ke Gustafsson and Karin Dahlman-Wright},
  journal={Cancer research},
  year={2010},
  volume={70 12},
  pages={5174-83}
}
Estrogen signaling can occur through a nonclassical pathway involving the interaction of estrogen receptors (ER) with other transcription factors such as activator protein-1 (AP-1) and SP-1. However, there is little mechanistic understanding about this pathway, with conflicting results from in vitro investigations. In this study, we applied the ChIP-on-chip approach to identify ERbeta-binding sites on a genome-wide scale, identifying 1,457 high-confidence binding sites in ERbeta-overexpressing… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

The genome landscape of ERα- and ERβ-binding DNA regions

  • Y Liu, H Gao, TT Marstrand
  • Proc Natl Acad Sci U S A 2008;105:2604–9
  • 2008
Highly Influential
4 Excerpts

American Association for Cancer 2010;70:5174-5183

  • Cancer Res Chunyan Zhao, Hui Gao, Yawen Liu
  • Available from: http://research.dfci.harvard.edu…
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…