Genome-wide mRNA surveillance is coupled to mRNA export.

  title={Genome-wide mRNA surveillance is coupled to mRNA export.},
  author={Haley Hieronymus and Michael Chiwei Yu and Pamela A. Silver},
  journal={Genes & development},
  volume={18 21},
Nuclear export of mRNA is a central step in gene expression that shows extensive coupling to transcription and transcript processing. However, little is known about the fate of mRNA and its export under conditions that damage the DNA template and RNA itself. Here we report the discovery of four new factors required for mRNA export through a screen of all annotated nonessential Saccharomyces cerevisiae genes. Two of these factors, mRNA surveillance factor Rrp6 and DNA repair protein Lrp1, are… CONTINUE READING

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