Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates

@article{Zandi2007GenomewideLS,
  title={Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates},
  author={Peter P. Zandi and Judith A. Badner and J Steele and Virginia L. Willour and Kuangyi Miao and Dean F. Mackinnon and Francis Mark Mondimore and Barbara Schweizer and Melvin G. McInnis and J Raymond Depaulo and ES Gershon and Francis J. McMahon and James B. Potash},
  journal={Molecular Psychiatry},
  year={2007},
  volume={12},
  pages={630-639}
}
Despite compelling evidence that genetic factors contribute to bipolar disorder (BP), attempts to identify susceptibility genes have met with limited success. This may be due to the genetic heterogeneity of the disorder. We sought to identify susceptibility loci for BP in a genome-wide linkage scan with and without clinical covariates that might reflect the underlying heterogeneity of the disorder. We genotyped 428 subjects in 98 BP families at the Center for Inherited Disease Research with 402… CONTINUE READING

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