Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.

@article{Shojaee2008GenomewideLA,
  title={Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.},
  author={Seyedmehdi Shojaee and Farzad Sina and Setareh Sadat Banihosseini and Mohammad Hossein Kazemi and Reza Kalhor and Gholam-Ali Shahidi and H Fakhrai-rad and Mostafa Ronaghi and Elahe Elahi},
  journal={American journal of human genetics},
  year={2008},
  volume={82 6},
  pages={1375-84}
}
Robust SNP genotyping technologies and data analysis programs have encouraged researchers in recent years to use SNPs for linkage studies. Platforms used to date have been 10 K chip arrays, but the possible value of interrogating SNPs at higher densities has been considered. Here, we present a genome-wide linkage analysis by means of a 500 K SNP platform. The analysis was done on a large pedigree affected with Parkinsonian-pyramidal syndrome (PPS), and the results showed linkage to chromosome… CONTINUE READING