Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders.

@article{Camp2005GenomewideLA,
  title={Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders.},
  author={Nicola J. Camp and Michael R. Lowry and Roberta L Richards and Agnes M Plenk and Catherine Alexandra Carter and Charles H. Hensel and Victor Abkevich and Mark H. Skolnick and Donna M. Shattuck and Kerry G Rowe and Dana C. Hughes and Lisa A. Cannon-Albright},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={135B 1},
  pages={85-93}
}
Major depressive disorder (MDD) is a common, clinically heterogeneous disorder often found comorbid with other disorders. We studied recurrent, early-onset MDD (MDD-RE) and anxiety disorders in combination to define powerful phenotypes for genetic study. We used 87 large, extended Utah pedigrees to investigate linkage to 3 phenotypes: "MDD-RE;" "MDD-RE or anxiety;" and "MDD-RE and anxiety;" where in the latter definition the disorders must appear comorbid within an individual. Pedigrees ranged… CONTINUE READING

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