Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.

@article{Lipchina2011GenomewideIO,
  title={Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.},
  author={Inna Lipchina and Yechiel Elkabetz and Markus Hafner and Robert Sheridan and Aleksandra Mladenovi{\'c} Mihailovi{\'c} and Thomas Tuschl and Chris Sander and Lorenz P Studer and Doron Betel},
  journal={Genes & development},
  year={2011},
  volume={25 20},
  pages={2173-86}
}
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives… CONTINUE READING
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Genome - wide identification of Ago 2 binding sites from mouse embryonic stem cells with and without mature microRNAs

  • Lin S-L, DC Chang, Lin C-H, Ying S-Y, D Leu, Wu DTS
  • Nat Struct Mol Biol
  • 2011

Coac - tivation of nuclear receptors and myogenic factors induces the major BTG 1 influence on muscle differentiation

  • E Cerami, E Demir, N Schultz, BS Taylor, C Sander
  • Oncogene
  • 2010
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