Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors

@article{GamaCarvalho2006GenomewideIO,
  title={Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors},
  author={Margarida Gama-Carvalho and Nuno L. Barbosa-Morais and Alexander Brodsky and Pamela A. Silver and Maria Carmo-Fonseca},
  journal={Genome Biology},
  year={2006},
  volume={7},
  pages={R113 - R113}
}
Pre-mRNA splicing is an essential step in gene expression that occurs co-transcriptionally in the cell nucleus, involving a large number of RNA binding protein splicing factors, in addition to core spliceosome components. Several of these proteins are required for the recognition of intronic sequence elements, transiently associating with the primary transcript during splicing. Some protein splicing factors, such as the U2 small nuclear RNP auxiliary factor (U2AF), are known to be exported to… CONTINUE READING

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