Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia

@article{Kuang2008GenomewideIO,
  title={Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia},
  author={S-Q Kuang and W Tong and Hui Yang and W S Lin and Ming-Shyue Lee and Zhi Hong Fang and Yu-Quan Wei and Jaroslav Jelinek and J-P J Issa and Guillermo Garcia-Manero},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={1529-1538}
}
We performed a genome-wide analysis of promoter associated CpG island methylation using methylated CpG island amplification (MCA) coupled to representational differential analysis (RDA) or a DNA promoter microarray in acute lymphoblastic leukemia (ALL). We identified 65 potential targets of methylation with the MCA/RDA approach, and 404 with the MCA/array. Thirty-six (77%) of the genes identified by MCA/RDA were shared by the MCA/array approach. Chromosomal location of these genes was evenly… CONTINUE READING
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