Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

@article{Tanimoto2010GenomewideIA,
  title={Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing},
  author={Kousuke Tanimoto and Katsuya Tsuchihara and Akinori Kanai and Takako Arauchi and Hiroyasu Esumi and Yutaka Suzuki and Sumio Sugano},
  journal={The HUGO Journal},
  year={2010},
  volume={4},
  pages={35-48}
}
We identified 531 and 616 putative HIF-1α target sites by ChIP-Seq in the cancerous cell line DLD-1 and the non-cancerous cell line TIG-3, respectively. We also examined the positions and expression levels of transcriptional start sites (TSSs) in these cell lines using our TSS-Seq method. We observed that 121 and 48 genes in DLD-1 and TIG-3 cells, respectively, had HIF-1α binding sites in proximal regions of the previously reported TSSs that were up-regulated at the transcriptional level. In… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 61 references

Nucleosome positioning and gene regulation: advances through genomics

Nature Reviews Genetics • 2009
View 7 Excerpts
Highly Influenced

Integration of oxygen signaling at the consensus HRE.

Science's STKE : signal transduction knowledge environment • 2005
View 4 Excerpts
Highly Influenced

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