Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol

  title={Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol},
  author={Qian S Zhang and Brian L. Browning and Sharon R. Browning},
  journal={European Journal of Human Genetics},
We performed genome-wide tests for association between haplotype clusters and each of 9 metabolic traits in a cohort of 5402 Northern Finnish individuals genotyped for 330 000 single-nucleotide polymorphisms. The metabolic traits were body mass index, C-reactive protein, diastolic blood pressure, glucose, high-density lipoprotein (HDL), insulin, low-density lipoprotein (LDL), systolic blood pressure, and triglycerides. Haplotype clusters were determined using Beagle. There were LDL-associated… 

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