Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

  title={Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease},
  author={J C Lambert and Benjamin Grenier-Boley and Denise Harold and Diana Z{\'e}l{\'e}nika and Vincent Chouraki and Yoichiro Kamatani and Kristel Sleegers and M. Arfan Ikram and Mikko Hiltunen and Christiane Reitz and Ignacio Mateo and Thomas Feulner and Mar{\'i}a J Bullido and Daniela Galimberti and Letizia Concari and V. Gonz{\'a}lez {\'A}lvarez and Rebecca J. A. Sims and A Gerrish and Jade A. Chapman and C{\'a}ndida D{\'e}niz-Naranjo and Vincenzo Solfrizzi and Sandro Sorbi and Beatrice Arosio and Gianfranco Spalletta and Gabriele Siciliano and Jacques Epelbaum and Didier Hannequin and J F Dartigues and Christophe Tzourio and C Berr and Elisabeth M. C. Schrijvers and Rachel E Rogers and Giuseppe Tosto and Florence Pasquier and Karolien Bettens and C Van Cauwenberghe and Laura Fratiglioni and Caroline Graff and Marc D{\'e}l{\'e}pine and Raffaele Ferri and Chandra A. Reynolds and Lars Lannfelt and Martin Ingelsson and Jonathan A. Prince and Caterina Chillotti and Alberto Pilotto and Davide Seripa and Anne Boland and M Mancuso and Paola Boss{\`u} and Giorgio Annoni and Benedetta Nacmias and P. I. Bosco and Francesco Panza and Florentino S{\'a}nchez-Garc{\'i}a and Maria Del Zompo and Elicer Coto and M S Owen and Michael O'Donovan and Fernando Valdivieso and P Caffara and Elio Scarpini and Onofre Combarros and Luc Bu{\'e}e and Dominique Campion and Hilkka Soininen and M. R. ten Breteler and Matthias Riemenschneider and Christine van Broeckhoven and Annick Alp{\'e}rovitch and Mark Lathrop and D-A Tr{\'e}gou{\"e}t and Jennet Williams and Philippe Amouyel},
  booktitle={Molecular Psychiatry},
Recently, several genome-wide association studies (GWASs) have led to the discovery of nine new loci of genetic susceptibility in Alzheimer's disease (AD). However, the landscape of the AD genetic susceptibility is far away to be complete and in addition to single-SNP (single-nucleotide polymorphism) analyses as performed in conventional GWAS, complementary strategies need to be applied to overcome limitations inherent to this type of approaches. We performed a genome-wide haplotype association… CONTINUE READING
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