Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum.

@article{Grimmler2011GenomewideGE,
  title={Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum.},
  author={Christina Grimmler and Holger Janssen and D{\'e}sir{\'e}e Krausse and Ralf-J{\"o}rg Fischer and Hubert Bahl and Peter D{\"u}rre and Wolfgang Liebl and Armin Ehrenreich},
  journal={Journal of molecular microbiology and biotechnology},
  year={2011},
  volume={20 1},
  pages={
          1-15
        }
}
Clostridium acetobutylicum is able to switch from acidogenic growth to solventogenic growth. We used phosphate-limited continuous cultures that established acidogenic growth at pH 5.8 and solventogenic growth at pH 4.5. These cultures allowed a detailed transcriptomic study of the switch from acidogenesis to solventogenesis that is not superimposed by sporulation and other growth phase-dependent parameters. These experiments led to new insights into the physiological role of several genes… CONTINUE READING

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