Genome-wide functional analysis using the barcode sequence alignment and statistical analysis (Barcas) tool

@inproceedings{Mun2016GenomewideFA,
  title={Genome-wide functional analysis using the barcode sequence alignment and statistical analysis (Barcas) tool},
  author={Jihyeob Mun and Dong-Uk Kim and Kwang-Lae Hoe and Seon-Young Kim},
  booktitle={BMC Bioinformatics},
  year={2016}
}
Pooled library screen analysis using shRNAs or CRISPR-Cas9 hold great promise to genome-wide functional studies. While pooled library screens are effective tools, erroneous barcodes can potentially be generated during the production of many barcodes. However, no current tools can distinguish erroneous barcodes from PCR or sequencing errors in a data preprocessing step. We developed the Barcas program, a specialized program for the mapping and analysis of multiplexed barcode sequencing (barcode… CONTINUE READING

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