Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker.

@article{Morag2011GenomewideEP,
  title={Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker.},
  author={Ayelet Morag and Metsada Pasmanik-Chor and Varda Oron-Karni and Moshe Rehavi and Julia C. Stingl and David Gurwitz},
  journal={Pharmacogenomics},
  year={2011},
  volume={12 2},
  pages={171-84}
}
AIMS Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used class of antidepressants for treating major depression. However, approximately 30% of patients do not respond sufficiently to first-line antidepressant drug treatment and require alternative therapeutics. Genome-wide studies searching for SSRI response DNA biomarkers or studies of candidate serotonin-related genes so far have given inconclusive or contradictory results. Here, we present an alternative transcriptome… CONTINUE READING
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