Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses.

@article{Wagner2004GenomewideEP,
  title={Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses.},
  author={Roger A. Wagner and Raymond Tabibiazar and Jennifer Powers and Daniel Bernstein and Thomas Quertermous},
  journal={Journal of molecular and cellular cardiology},
  year={2004},
  volume={37 6},
  pages={1159-70}
}
Cardiac hypertrophy is a predictor of cardiovascular morbidity and mortality independent of other risk factors. Pressure overload induces the development of left ventricular hypertrophy (LVH) and left atrial enlargement (LAE) in the mammalian heart. To systematically investigate the transcriptional changes, which mediate these processes, we have performed a genome-wide transcriptional profiling of each of the four heart chambers from mice subjected to transverse aortic constriction (TAC). A… CONTINUE READING

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