Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.

@article{Sordillo2015GenomewideEP,
  title={Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.},
  author={J E Sordillo and Roxanne K Kelly and Supinda Bunyavanich and Michael J. McGeachie and Weiliang Qiu and Damien C. Croteau-Chonka and Manuel E. Soto-Quiros and Lydiana Avila and Juan C Celed{\'o}n and John Brehm and Scott T. Weiss and Diane R. Gold and Augusto A Litonjua},
  journal={The Journal of allergy and clinical immunology},
  year={2015},
  volume={136 4},
  pages={
          885-92.e2
        }
}
BACKGROUND Gene-environment interaction studies using genome-wide association study data are often underpowered after adjustment for multiple comparisons. Differential gene expression in response to the exposure of interest can capture the most biologically relevant genes at the genome-wide level. OBJECTIVE We used differential genome-wide expression profiles from the Epidemiology of Home Allergens and Asthma birth cohort in response to Der f 1 allergen (sensitized vs nonsensitized) to inform… CONTINUE READING
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