Genome-wide expression monitoring in Saccharomyces cerevisiae

  title={Genome-wide expression monitoring in Saccharomyces cerevisiae},
  author={Lisa M Wodicka and Helin Dong and Michael Mittmann and Ming-Hsiu Ho and David J Lockhart},
  journal={Nature Biotechnology},
The genomic sequence of the budding yeast Saccharomyces cerevisiae has been used to design and synthesize high-density oligonucleotide arrays for monitoring the expression levels of nearly all yeast genes. This direct and highly parallel approach involves the hybridization of total mRNA populations to a set of four arrays that contain a total of more than 260,000 specifically chosen oligonucleotides synthesized in situ using light-directed combinatorial chemistry. The measurements are… CONTINUE READING
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