Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis.

@article{Hiratani2010GenomewideDO,
  title={Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis.},
  author={Ichiro Hiratani and Tyrone Ryba and Mari Itoh and Joy Rathjen and Michael Kulik and Bernadett Papp and Eden Fussner and D. P. Bazett-Jones and Kathrin Plath and Stephen Dalton and Peter David Rathjen and David M. Gilbert},
  journal={Genome research},
  year={2010},
  volume={20 2},
  pages={155-69}
}
Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed genome-wide replication-timing profiles of 22 independent mouse cell lines representing 10 stages of early mouse development, and transcription profiles for seven of these stages. Replication profiles were cell-type specific, with 45% of the genome exhibiting significant changes at some point… CONTINUE READING

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Role of the murine reprogramming factors

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