Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation.

@article{Weng2013GenomewideDO,
  title={Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation.},
  author={Liming Weng and Dana M Ziliak and Hae Kyung Im and Eric R. Gamazon and Sanosh Philips and Anthony T. Nguyen and Zeruesenay Desta and Todd C. Skaar and David A. Flockhart and R. Stephanie Huang},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2013},
  volume={24 7},
  pages={1867-73}
}
BACKGROUND Beyond estrogen receptor (ER), there are no validated predictors for tamoxifen (TAM) efficacy and toxicity. We utilized a genome-wide cell-based model to comprehensively evaluate genetic variants for their contribution to cellular sensitivity to TAM. DESIGN Our discovery model incorporates multidimensional datasets, including genome-wide genotype, gene expression, and endoxifen-induced cellular growth inhibition in the International HapMap lymphoblastoid cell lines (LCLs). Genome… CONTINUE READING
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Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for original articles Annals of Oncology

  • L Fasquelle, HS Scott, M Lenoir
  • J Biol Chem
  • 2011
Highly Influential
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