Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparum.

@article{Mourier2008GenomewideDA,
  title={Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparum.},
  author={Tobias Mourier and Celine Carret and Sue A Kyes and Z{\'o}e Christodoulou and Paul P. Gardner and Daniel C Jeffares and Robert A. Pinches and Bart Barrell and Matthew Berriman and Sam Griffiths-Jones and Alasdair Ivens and Chris I Newbold and Arnab Pain},
  journal={Genome research},
  year={2008},
  volume={18 2},
  pages={281-92}
}
We undertook a genome-wide search for novel noncoding RNAs (ncRNA) in the malaria parasite Plasmodium falciparum. We used the RNAz program to predict structures in the noncoding regions of the P. falciparum 3D7 genome that were conserved with at least one of seven other Plasmodium spp. genome sequences. By using Northern blot analysis for 76 high-scoring predictions and microarray analysis for the majority of candidates, we have verified the expression of 33 novel ncRNA transcripts including… CONTINUE READING
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