Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.

Abstract

Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in low genome coverage. Here, we report on a new amplification method-multiple annealing and looping-based amplification cycles (MALBAC… (More)
DOI: 10.1126/science.1229164

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Cite this paper

@article{Zong2012GenomewideDO, title={Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.}, author={Chenghang Zong and Sijia Lu and Alec R. Chapman and X. Sunney Xie}, journal={Science}, year={2012}, volume={338 6114}, pages={1622-6} }